It depends. It is resistant to virtually all aqueous media including dilute acids and alkalis and to methanol, ethanol and silicone oils.
It has limited resistance to paraffin oil, vegetable oils, diesel fuel and vaseline, which may attack the surface of EPS after long-term contact.
It is not resistant to hydrocarbons, ketones, esters, paints containing thinners, and solutions of synthetic adhesives.
In roof construction requiring hot asphalt, care should be taken to follow recommended installation instructions for hot bituminous asphalt to prevent melting or collapse of EPS insulation boards.